wellness

How a Genetic Test Helped Give Me Peace of Mind When I Was Struggling with My Mental Health

Through childhood, I had so many irrational worries to the point I'd be up all night, tossing and turning with the fear that something horrible was about to happen to me at any waking moment. As I grew up, I found those irrational fears—along with many others I’d incurred over the years—and the need for control in general did not subside. As much as I always wanted to “relax” (“relaxing”: a remedy people love to prescribe when they can’t empathize with your symptoms), I never could. My brain usually felt (and still sometimes feels) like a hamster wheel that never stops running. Seeing a few different therapists for years on and off, albeit helpful, was not enough—and although I really hated to admit it, the anxiety was seriously affecting my daily life and I needed additional help.

After talking to my primary care doctor, she prescribed me SSRIs—or Selective Serotonin Reuptake Inhibitors, medications commonly used for people with certain mental health conditions. However, after trying two different options over the course of a year, I was not convinced I had found the one. Both gave me side effects I was uncomfortable with, and I became worried I’d never find one that worked well and didn’t come with a laundry list of additional unwelcome symptoms (brain fog, lethargy and memory loss to name a few). Luckily, my therapist at the time suggested I ask my primary care doctor about the GeneSight® test—and the silver lining appeared. Anyone who’s taken SSRIs knows that it can often be a guessing game of what may or may not work. While Lexapro, for example, may work for my best friend, it may not work as well for me, which could be in part due to my genetic makeup—and that is exactly what the GeneSight test helps your clinician navigate.

How Does the GeneSight Test Work?

In 2022, my primary care doctor ordered the GeneSight test for me and had a kit sent directly to my house. They explained that after doing a simple swab of the mouth at home, I’d send my sample off to the lab to let the magic happen. I dropped my test off at a FedEx box, and in about a week, the results were sent to my doctor, who reviewed them with me. The report informed how my genes may impact my body’s ability to metabolize or respond to certain mental health medications. We discussed which medications may require dose adjustments, be less likely to work or have an increased risk of side effects based on my DNA. There are three categories that medicines will go into: Use as Directed, Moderate Gene-Drug Interaction and Significant Gene-Drug Interaction.

While we reviewed my results, my doctor and I discussed choosing a medication in the “Use as Directed” category. Knowing my doctor had genetic insights to help inform medication decision was reassuring. The stress of wondering if the medication will even work oftentimes made my anxiety symptoms worse, but thanks to the GeneSight test results, a path to my mental wellness became more accessible. And even though anxiety never really goes away, it has become much more manageable. I’m able to travel, host people in my home and do all the things I want to do without the fear of anxiety becoming my worst enemy again.

How Do I Get the GeneSight Test?

Since my primary care doctor ordered the GeneSight test, I was able to get answers to a question that once felt impossible to answer. Three years later, my mental health has improved significantly from that point, thanks to a proper diagnosis, therapy, lifestyle changes and a helpful course of SSRIs—which I never would have felt comfortable taking if not for the insights from the GeneSight test. I feel more in control of my mental health than ever before, and I owe a lot of it to the clarity the test provided.

If you are struggling with trial and error for your mental health medications, ask your clinician about the GeneSight test or fill out a form online. The results give your clinician key information, which may help reduce the number of medications you have to try before finding treatment success. It’s an important step forward on your mental wellness journey—just take it from someone who speaks from experience.

The GeneSight test must be ordered by and used only in consultation with a healthcare provider who can prescribe medications. Do not make any changes to your current medications or dosing without consulting your healthcare provider. As with all genetic tests, the GeneSight test results have limitations and do not constitute medical advice. The test results are designed to be just one part of a larger, complete patient assessment, which would include proper diagnosis and consideration of your medical history, other medications you may be taking, your family history, and other factors.


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